TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
Tenofovir Alafenamide fumarate
CAS: 1392275-56-7
Molecular Formula: C25H33N6O9P
TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE) - Names and Identifiers
TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE) - Physico-chemical Properties
| Molecular Formula | C25H33N6O9P |
| Molar Mass | 592.55 |
| Solubility | DMSO |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT. |
| In vivo study | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) . |
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View History
TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
36265-41-5
丁二腈
208720-71-2
865-52-1
p-Tolualdehyde
93523-70-7
1009-15-0
36265-41-5
丁二腈
208720-71-2
865-52-1
p-Tolualdehyde
93523-70-7
1009-15-0